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. 2010 Jan 7;65(3):235–242. doi: 10.1111/j.1365-2044.2009.06207.x

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© 2010 The Authors. Journal compilation © 2010 The Association of Anaesthetists of Great Britain and Ireland

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Performance of ventilator iterations at I:E ratios of 1:2 (◆), 1:1 (▪) and 2:1 (). A, B: design (ii): effect of lung compliance on F _I o ₂. C, D: design (ii): oxygen consumption increases marginally with increased lung compliance (increased ventilator workload). E, F: design (iii): the F _I co ₂ (a surrogate for NO in this experiment) was maintained within a narrow range (3–3.8%), suggesting that a stable F _INO within acceptable safe limits could be delivered by a design of this type if supplied with appropriately diluted NO.