Table 1.
Examples of vaccines manufactured using animal cells
| Vaccine type | Description | Cells | Status | Ref. |
|---|---|---|---|---|
| Live/Attenuated | Oral polio vaccine (OPV) – Attenuated vaccine produced by the passage of the virus through non‐human cells | Vero | Licensed | [119] |
| RotaTeq® – Pentavalent vaccine containing (five) live attenuated reassortant rotaviruses | Vero | Licensed | [120] | |
| Varilix® – Lyophilized preparation of attenuated virus derived from the Oka strain, vaccine against varicella | MRC5 | Licensed | [121] | |
| smallpox vaccine ACAM2000 – Attenuated vaccinia‐based smallpox vaccine | Vero | Licensed | [122] | |
| Inactivated | Imovax® – Monovalent vaccine containing inactivated rabies | MRC5 | Licensed | [123] |
| Havrix® – Inactivated hepatitis A vaccine with formaldehyde | MRC5 | Licensed | [124] | |
| Inactivated polio vaccine (IPV) – Trivalent inactivated poliovirus | Vero | Licensed | [125] | |
| Optaflu® –Trivalent cell culture‐derived influenza vaccine | MDCK | Licensed | [90] | |
| Subunit Protein | Flublok® –Recombinant trivalent hemagglutinin (rHA) vaccine produced in insect cell culture using BEVs | expresSF+ | Licensed | [22] |
| Glycoprotein B – recombinant truncated secreted form of gB | CHO | Phase II | [126] | |
| DEN1‐80E – Adjuvanted recombinant envelope protein vaccine to protect against dengue virus | Drosophila S2 | Phase I | [127] | |
| Subunit VLP | GenHevacB® – Vaccine agents hepatitis B composed of PreS1 and preS2 of HBV S‐antigen assembled into HBV‐like particles | CHO | Licensed | [9] |
| Cervarix® – Vaccine against HPV infection composed of HPV L1 capsid protein from HPV16 and HPV18 assembled into a HPV‐like particle | High5 | Licensed | [11] | |
| NCT01596725 – Influenza backbone (M1 structural protein) displaying HA and NA of influenza H1N1 | Sf9 | Phase I | [128] | |
| Subunit Vectored Vaccine | Ad26.ENVA.01 – Ad26 vector for the expression of a modified HIV env glycoprotein (gp140HIV‐1Clade A) | HER.96 | Phase II | [129] |
| ChimeriVAX® – Chimeric YF17D/DEN vaccine against dengue using an attenuated yellow fever virus as a vector coding for PrM and E genes from dengue | Vero | Phase III | [130] | |
| AVX601 – Vaccine against HCMV it uses alphavirus as vector for the expression of HCMV gB/pp65/IE1 | Vero | Phase I | [131] |