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Ultrastructural changes associated with viral replication or viral factories
(A) The Semliki forest virus, an alphavirus, induces the formation of a cytopathic vacuole (CPV), surrounded by the ER. Numerous viral replication complexes (arrow) are anchored in the internal membrane of the CPV. (B) The non‐structural proteins of HCV, a flavivirus, induce the formation of a membranous web in the perinuclear area.
