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. Author manuscript; available in PMC: 2021 Mar 17.
Published in final edited form as: Anal Chem. 2020 Mar 5;92(6):4436–4444. doi: 10.1021/acs.analchem.9b05388

Figure 2. Tandem mass spectra and summary fragmentation profiles for a short, modified ribonucleic acid with various activation methods.

Figure 2.

(A) MS/MS spectra of the 6-nucleotide modified RNA after 50ms of NETD, (B) 50ms of AI-NETD at 6 W, (C) CAD, and (D) HCD. Note each panel presents a spectrum that results from averaging 20 single-scan spectra and are shown on the same intensity scale. Charge-reduced intact species’ peaks are indicated by brackets in grey text. (E) Summary of product ion distributions, based on relative intensity, for the various activation methods.