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. Author manuscript; available in PMC: 2021 Mar 17.
Published in final edited form as: Anal Chem. 2020 Mar 5;92(6):4436–4444. doi: 10.1021/acs.analchem.9b05388

Figure 4. Fragmentation profiles for NETD, AI-NETD, and HCD of the 21-nucleotide luciferase siRNA antisense strand.

Figure 4.

The four pairs of complementary fragment types are displayed for (A) NETD, (B) AI-NETD, and (C) HCD tandem mass spectrometry dissociation. Sequence coverage denotes the percentage of phosphodiester bond cleavage using all eight product types.