Table 2. Maternal report of child’s atopic dermatitis, asthma and hay fever: Adjusted odds ratios (OR) for offspring risk of atopic dermatitis during childhood and adolescence according to maternal rotating night shiftwork history before pregnancy, restricted to singleton, full-term births.
| History of rotating night shift work | ||||||
|---|---|---|---|---|---|---|
| Never worked rotating night shifts | <3 yrs | 3–5 yrs | ≥6 yrs | P trend | Ever worked rotating night shifts | |
| Maternal report of child’s atopic dermatitis* | ||||||
| OR (95% CI) | ||||||
| Cases/participants | 190/1,683 | 157/1,507 | 133/1,132 | 57/491 | 347/3,130 | |
| Basic model a | 1 (reference) | 0.90 (0.71; 1.13) | 1.03 (0.80; 1.31) | 1.04 (0.76; 1.43) | 0.56 | 0.97 (0.80; 1.17) |
| MV model 1b | 1 (reference) | 0.91 (0.72; 1.15) | 1.04 (0.81; 1.33) | 1.04 (0.75; 1.44) | 0.58 | 0.98 (0.80; 1.19) |
| MV model 2c | 1 (reference) | 0.90 (0.71; 1.14) | 1.06 (0.82; 1.36) | 1.06 (0.76; 1.47) | 0.46 | 0.98 (0.80; 1.19) |
| Maternal report of child’s asthma* | ||||||
| OR (95% CI) | ||||||
| Cases/participants | 248/1,683 | 245/1,507 | 170/1,132 | 87/491 | 502/3,130 | |
| Basic model a | 1 (reference) | 1.12 (0.92; 1.37) | 1.02 (0.82; 1.27) | 1.24 (0.94; 1.62) | 0.40 | 1.10 (0.93; 1.31) |
| MV model 1b | 1 (reference) | 1.12 (0.91; 1.36) | 1.00 (0.81; 1.25) | 1.22 (0.92; 1.61) | 0.51 | 1.09 (0.92; 1.29) |
| MV model 2c | 1 (reference) | 1.10 (0.90; 1.36) | 1.01 (0.81; 1.27) | 1.27 (0.95; 1.70) | 0.37 | 1.09 (0.92; 1.31) |
| Maternal report of child’s hay fever* | ||||||
| OR (95% CI) | ||||||
| Cases/participants | 274/1,683 | 264/1,507 | 178/1,132 | 85/491 | 527/3,130 | |
| Basic model a | 1 (reference) | 1.10 (0.91; 1.34) | 0.96 (0.78; 1.19) | 1.07 (0.81; 1.40) | 0.82 | 1.05 (0.89; 1.23) |
| MV model 1b | 1 (reference) | 1.11 (0.92; 1.35) | 0.96 (0.77; 1.19) | 1.11 (0.84; 1.46) | 0.96 | 1.06 (0.89; 1.25) |
| MV model 2c | 1 (reference) | 1.10 (0.89; 1.35) | 0.99 (0.78; 1.25) | 1.16 (0.86; 1.57) | 0.74 | 1.07 (0.89; 1.28) |
*Assessed in 2009 from GUTS Mothers’ questionnaire; Defined as physician-diagnosed eczema (atopic dermatitis), asthma, hay fever
Abbreviations: CI, confidence interval; OR, odds ratio; MV, multivariable model
a Adjusted for offspring gender (boy/girl) and offspring age at GUTS baseline 2004
b Additionally adjusted for maternal age at pregnancy, smoking status before pregnancy (never, current, past), alternative healthy eating score (quintiles), physical activity (METs hours/week; quintiles), husband’s education (less than 2yr college, 4yr college, grad school), parity (nulliparity, 1, 2, 3+ previous pregnancies), BMI before pregnancy (<25, 25–29, ≥30 kg/m2), geographic region of residence (West, Midwest (reference), South, Northeast) and Census tract education rate in 1989
c Additionally adjusted for parental diagnosis of eczema, asthma and hay fever (yes/no)