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. 2020 Apr 16;15(4):e0231716. doi: 10.1371/journal.pone.0231716

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© 2020 Cerchione et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) Dose-response of indel fraction at the known off-target locus evolved against during phage-based selection. SpartaCas shows similar reduction in off-target editing to eCas9. (B) Dose-response of indel fraction at the on-target locus PD49. (C) On-target editing efficiency compared between wild-type and high-fidelity variants. SpartaCas maintains higher or similar editing efficiency to eCas9 and substantially higher efficiency than HF4. All experiments were performed in technical triplicates. Bars shown indicate standard error.