Table 1.
| Pharmacokinetic parameter | N | Mean | SD | Median | Min | Max |
|---|---|---|---|---|---|---|
| Serum | ||||||
| Cmax (mg/L) | 11 | 2.84 | 0.52 | 2.74 | 2.08 | 3.55 |
| Tmax (h) | 11 | 1.59 | 0.86 | 1.00 | 0.50 | 3.00 |
| AUC0–4 (mg/L*h) | 11 | 9.04 | 1.56 | 9.02 | 6.52 | 11.55 |
| Prostatic secretion | ||||||
| Concentration prostatic secretion (mg/L) | 8 | 3.79 | 1.24 | 3.99 | 2.00 | 5.57 |
| Ratio prostatic secretion/seruma | 8 | 1.61 | 0.51 | 1.57 | 0.97 | 2.32 |
| Ejaculate | ||||||
| Concentration ejaculate (mg/L) | 10 | 2.46 | 0.35 | 2.49 | 1.94 | 2.97 |
| Ratio ejaculate/seruma | 10 | 1.02 | 0.18 | 1.01 | 0.77 | 1.31 |
a
Corresponding serum concentrations were linearly extrapolated from serum concentrations at 3 and 4 h.