Occurrences of resistance to Q-D and MUP among staphylococci and E. faecium (1997–2006)
| Org./Antim.-R (no.) | Year (%non-S)a |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | |
| SA | ||||||||||
| OX-S/Q-D (11.967) | 0.3 (1.0)b | 0.1 | 0.0 | 0.3 | 0.2 | <0.1 | <0.1 | 0.3 | 0.2 | 0.2 |
| OX-R/Q-D (4,813) | 4.3 | 4.9 | 5.9 | 4.3 | 3.7 | 2.2 | 0.8 | 1.1 | 1.3 | 1.3 |
| OX-S/MUP (9,399) | − | − | − | 0.6 | 0.5 | 1.0 | 0.9 | 1.0 | 0.6 | 0.7 |
| OX-R/MUP (3,903) | − | − | − | 14.6 | 11.1 | 12.1 | 10.6 | 7.7 | 7.2 | 6.2 |
| CoNS | ||||||||||
| OX-S/Q-D (1,822) | 1.0c | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| OX-R/Q-D (5,517) | 1.3 | 1.0 | 0.5 | 3.1 | 0.6 | 1.1 | 0.7 | 0.7 | 0.7 | 2.1 |
| OX-S/MUP (1,269) | − | − | − | 5.1 | 10.5 | 5.4 | 4.2 | 3.5 | 5.2 | 2.0 |
| OX-R/MUP (3,994) | − | − | − | 16.7 | 21.8 | 25.4 | 17.7 | 18.8 | 18.3 | 21.4 |
| EFM/Q-D (1,361) | 20.3 | 26.1 (50.0)d | 22.7 | 18.7 | 25.5 | 26.3 | 23.6 | 27.4 | 29.5 | 30.2 |
a
Non-susceptibility % based upon the CLSI interpretive criteria for Q-D (M100-S16) and MUP at MIC values ≥16 mg/L (high- and low-level rates combined).
b
Clonal outbreak in France increased the prevalence to 1%.
c
Three isolates from different countries with intermediate MIC values (2 mg/L).
d
A large number of clonally disseminated strains in Austria, Germany, Italy, Portugal and Spain produced a higher percentage of non-susceptible isolates.