Organism	Phenotypea	RO4908463 MIC parameter (mg/L)
		EU			USA
		Total n	Range	MIC90	Total n	Range	MIC90
S. aureus	All	312	0.06–>32	16	333	0.06–32	4
	MRSA	161	0.5–>32	16	172	0.25–32	4
	MSSA	151	0.06–2	0.25	161	0.06–2	0.25
S. epidermidis	All	56	0.06–16	1	56	0.03–8	4
	MRSE	23	0.06–16	4	29	0.06–8	4
	MSSE	33	0.06–0.06	0.06	27	0.03–0.12	0.12
E. faecalis		51	0.06–>32	4	54	0.03–4	4
E. faecium		30	4–>32	>32	30	0.06–>32	>32
S. pneumoniae	All	52	≤0.008–1	0.5	55	≤0.008–1	1
	PEN-S	32	≤0.008–0.03	≤0.008	32	≤0.008–0.03	0.015
	PEN-NS	20	0.03–1	0.5	23	0.25–1	1
S. pyogenes		47	≤0.008–0.015	0.015	51	≤0.008–0.06	0.015
S. agalactiae		51	0.015–0.06	0.06	53	0.03–0.06	0.06

^aMR, methicillin-resistant; MS, methicillin-susceptible; PEN, penicillin; S, susceptible; NS, non-susceptible.