| Drugs (Cmax*) | ATCC 25923 (MSSA) |
NRS 192 (CA-MRSA) |
||
|---|---|---|---|---|
| MIC (mg/L) | intracell. activity (Δ log cfu) | MIC (mg/L) | intracell. activity (Δ log cfu) | |
| TMP-SMX (25) | 1 | +0.6±0.1 | 1–2 | +0.7±0.0 |
| CLX (8) | 0.125 | −0.8±0.1 | 0.5–1 | −0.07±0.1 |
| LNZ (21) | 1 | −0.7±0.1 | 2 | −0.7±0.1 |
| CLI (12) | 0.06 | −1.0±0.1 | 0.125 | −0.9±0.1 |
| CIP (4) | 0.125 | −1.3±0.1 | 0.5 | −1.4±0.1 |
| MXF (4) | 0.03 | −2.0±0.0 | 0.03 | −1.8±0.1 |
*
As commonly observed in humans after conventional administration and used as extracellular concentration (total drug) to assess intracellular activity.