| Condition | Cc/Ce (% control in wild-type cells) |
|||
|---|---|---|---|---|
| wild-type cells |
CIP-resistant cells |
|||
| CIP | DOX | CIP | DOX | |
| Control (drug conc. 50 μM) | 100±1 | 100±8 | 10±2* | 98±10ns |
| + PB (5 mM) | 335±24* | 178±41* | 225±41* | 195±16ns |
| + DOX (total conc. 75 μMa) | 101±2ns | 135±16* | ||
| + ClP (total conc. 500 μMa) | 494±43* | 105±6ns | ||
Statistical analysis: (i) wild-type cells: differences with control values; (ii) CIP-resistant cells: differences with the corresponding values in wild-type cells;
nsnon-significant.
a
Highest testable conc. (limit of solubility).
*
p < 0.05