Activity of telavancin against Streptococcus pneumoniae (SP), viridans streptococci (VGS) and β-haemolytic streptococci (BS) isolates
| Organism | Specimen sourcea | Phenotypeb | No. of isolates | MIC (mg/L) |
|
|---|---|---|---|---|---|
| Range | MIC90 | ||||
| SP | Blood | All | 52 | ≤0.001–0.06 | 0.03 |
| PEN-S | 44 | ≤0.001–0.06 | 0.03 | ||
| PEN-NS | 8 | 0.015–0.03 | NAc | ||
| LRT | All | 67 | 0.002–0.03 | 0.03 | |
| PEN-S | 42 | 0.002–0.03 | 0.03 | ||
| PEN-NS | 25 | 0.015–0.03 | 0.03 | ||
| URT | All | 49 | 0.008–0.03 | 0.03 | |
| PEN-S | 35 | 0.008–0.03 | 0.03 | ||
| PEN-NS | 14 | 0.015–0.03 | 0.03 | ||
| VGS | Blood | All | 40 | 0.03–0.5 | 0.12 |
| ERY-S | 21 | 0.03–0.5 | 0.12 | ||
| ERY-NS | 19 | 0.03–0.12 | 0.12 | ||
| SST | All | 27 | 0.015–0.5 | 0.06 | |
| ERY-S | 17 | 0.03– | |||
| 0.06–0.06 | |||||
| ERY-NS | 10 | 0.015–0.5 | 0.06 | ||
| BS | Blood | All | 26 | ≤0.001–0.25 | 0.06 |
| ERY-S | 21 | 0.015–0.25 | 0.06 | ||
| ERY-NS | 5 | ≤0.001–0.06 | Nac | ||
| SST | All | 80 | 0.002–0.12 | 0.06 | |
| ERY-S | 59 | 0.002–0.12 | 0.06 | ||
| ERY-NS | 21 | 0.015–0.12 | 0.06 | ||
a
LRT, lower respiratory tract; URT, upper respiratory tract; SST, skin structure.
b
PEN-S/PEN-NS, penicillin-susceptible/nonsusceptible; ERY-S/ERY-NS, erythromycin-susceptible/nonsusceptible.
c
NA, not available; MIC90 values were not determined for <10 isolates.