Common treatment-related AEs (>3 patients in either group)
| MICA (N = 264), n (%) | L-AmB (N = 267), n (%) | P-value | |
|---|---|---|---|
| Fever | 23 (8.7) | 36 (13.5) | NS |
| Chills | 3 (0.8) | 17 (6.4) | <0.05* |
| Back pain | 1 (0.4) | 12 (4.5) | <0.05* |
| Nausea | 12 (4.5) | 10 (3.7) | NS |
| LFT abnormal | 11 (4.2) | 5 (1.9) | NS |
| Vomiting | 9 (3.4) | 9 (3.4) | NS |
| Hypokalaemia | 18 (6.8) | 32 (12.0) | NS |
| Increased creatinine | 5 (1.9) | 17 (6.4) | <0.05* |
| Increased SGPT | 5 (1.9) | 1 (0.4) | NS |
| Increased LD | 4 (1.5) | 3 (1.1) | NS |
| Dyspnoea | 3 (1.1) | 6 (2.2) | NS |
| Rash | 4 (1.5) | 7 (2.6) | NS |
| Skin erythema | 1 (0.4) | 4 (1.5) | NS |
NS: not significant;
*
Fisher exact test.