Relationship between serum fibrosis markers (hyaluronic acid [HA] and MMP2) and pathological assessment

		HA (ng/mL)	MMP2 (ng/mL)
Cirrhosis
Cirrhotic	N	6	4
	Median (min–max)	61 (15–160)	100 (100–4,200)
	Mean±SD	72.1±50.8	1,125±2,050
Non-cirrhotic	N	36	35
	Median (min–max)	25 (5–375)	130 (100–18,000)
	Mean±SD	57±88.7	2,699±4,688.7
Total	N	42	39
	Median (min–max)	26 (5–375)	100 (100–18,000)
P-valuea	Mean±SD	59.1±84.0 0.075	2,537.0±4,498.4 0.407
Histological activity
Minimal/absent hepatitis	N	6	6
	Median (min–max)	20 (10–45)	150 (100–9,000)
	Mean±SD	22.5±12.6	2,066.7±3,573.6
Moderate–severe hepatitis	N	30	29
	Median (min–max)	26 (5–375)	130 (100–18,000)
	Mean±SD	63.9±95.7	2,830.0±4930.6
Total	N	36	35
	Median (min–max)	25 (5–375)	130 (100–18,000)
P-valuea	Mean±SD	57±88.7 0.406	2,699±4,688.7 0.871

^aMann–Whitney U-test.