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. 2011 Apr 28;13(6):806–813. doi: 10.1111/j.1462-5822.2011.01596.x

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© 2011 Blackwell Publishing Ltd

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Schematic representation of the compartmentalized nucleus. The nucleus is bounded by the double‐membrane nuclear envelope. Nuclear pore complexes regulate nucleocytoplasmic exchange of macromolecules. Chromatin binds to the nuclear lamina that in turn is connected to the nuclear envelope. Nuclear matrix regulates spatial and functional organization of chromatin and nuclear bodies. The main nuclear bodies are represented: Nucleolus; the perinucleolar compartment; Cajal bodies, Gem, Polycomb body, Promyelocytic leukaemia (PML) bodies, Oct1/PTF/Transcription (OPT) domain, speckles and paraspeckles.