| Condition | Cellular accumulation (% drug alone in WT cells) |
|||
|---|---|---|---|---|
| WT cells |
CIP-resistant cells |
|||
| CIP | PMEA | CIP | PMEA | |
| Drug alone (50 μM) | 100±9 | 100±7 | 15±10 | 37±3 |
| + CIP 540 μM | − | 146±4 | − | 187±34 |
| + Bis(POM)PMEA 1000 μM | 170±21 | − | 141±28 | − |
| + SQV 300 μM | 414±32 | ND | 278±13 | ND |
| + RTV 300 μM | 112±13 | ND | 25±9 | ND |
Values in bold characters highlight values that are significantly different from those measured for the drug alone