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. 2009 Jun 11;11(10):1533–1549. doi: 10.1111/j.1462-5822.2009.01345.x

Figure 7.

Figure 7

Endocytic pathways utilized by DENV‐1 and DENV‐2 to infect different cell lines. DENV‐1 infection of Vero cells occurs through a classical clathrin‐mediated dynamin‐dependent endocytosis, while infection of this same cell line by DENV‐2 takes place through a non‐classical endocytic pathway independent of clathrin, caveolin‐1 and lipid‐rafts, but dependent on dynamin. This entry route differs from the clathrin‐mediated pathway followed by DENV‐2 to infect A549 cells and, as previously shown, to infect C6/36 cells (Acosta et al., 2008b; Mosso et al., 2008), HeLa cells (Krishnan et al., 2007) and BS‐C‐1 cells (van der Schaar et al., 2008).