Figure 4.

Indomethacin antiviral activity is independent of host protein expression.

A. Mock‐infected (−VSV) or VSV‐infected (+VSV) MA104 cells treated with 400 μM INDO after the 1 h adsorption period in the presence or absence of AMD (5 μg ml⁻¹) were labelled with [³⁵ S]‐methionine (2 h pulse) at 6 h p.i. Samples containing equal amounts of radioactivity were processed for SDS‐PAGE and autoradiography. VSV proteins L, G, N, NS and M are indicated.

B. Virus yield (TCID _50% ml⁻¹) was determined in parallel samples at 8 h p.i. Data represent the mean ± SD of duplicate samples from a representative experiment of two with similar results. *P < 0.01.