Table.

Investigation of carbapenem susceptibility by different methods in blaIMP-1 metallo-beta-lactamase positive Klebsiella pneumoniae isolates

	Strains
	Klb-21	Klb-62	Klb-73	Klb-85	Klb-200	Klb-201	Klb-202	Klb-223	Klb-232	Klb-234	Klb-266	Klb-275
MIC by broth dilution (ug/ml)
Imipenem	4	4	4	4	4	4	4	4	2	4	4	4
Meropenem	8	16	16	16	16	16	16	16	16	8	16	16
MIC by Etest (ug/ml)
Imipenem	1	0.5	0.5	0.5	0.38	0.75	0.38	0.75	0.5	1	0.75	1
Meropenem	2	0.5	0.5	0.5	0.75	1	0.5	0.75	1	2	1.5	1.5
Ertapenem	3	4	4	12	3	≥32	0.19	2	6	3	6	2
Doripenem	0.5	0.5	0.75	2	0.5	4	0.016	0.75	0.75	0.5	1	1
Disc diffusion zone diameter (mm)
Imipenem	18	19	20	17	21	19	22	19	20	18	19	18
Meropenem	19	18	19	19	18	19	20	19	18	18	17	19
Ertapenem	15	14	14	13	15	17	19	13	13	12	14	14
AST-GN09 card, Vitek 2 ver. AIX 4.01
Imipenem	8	8	≥16	≥16	≥16	≥16	≥16	≥16	≥16	≥16	≥16	8
Meropenem	1	1	2	2	2	2	≥16	2	8	2	2	2
Carbapenemase*	No	No	No	No	No	No	No	No	No	No	No	No
AST-GN09 card, Vitek 2 ver. AIX 4.03
Imipenem	8	4	2	8	4	4	2	8	8	4	4	8
Meropenem	2	2	1	4	2	1	1	4	4	4	2	2
Carbapenemase	No	Yes	No	Yes	Yes	No	No	Yes	Yes	No	Yes	Yes
AST-GN13 card, Vitek 2 ver. AIX 4.03
Imipenem	8	4	2	8	4	4	2	4	4	4	4	4
Ertapenem 4	≥8	≥	8	≥8	≥8	≥8	4	≥8	≥8	≥8	≥8	≥8
Carbapenemase	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
AST-GN09 card, Vitek 2 ver. PC 3.01
Imipenem	8	8	4	4	2	4	2	4	4	4	8	8
Meropenem	1	2	1	2	1	1	1	1	1	1	1	1
Carbapenemase	No	Yes	No	Yes	No	No	No	No	No	No	No	Yes
AST N091 card, Vitek 2 ver. PC 3.01
Imipenem	4	4	2	4	4	4	≤1	4	8	2	4	8
Meropenem	1	1	2	2	1	1	1	2	4	1	1	2
Ertapenem	4	≥8	≥8	≥8	≥8	≥8	4	≥8	≥8	≥8	≥8	≥8
Carbapenemase	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
AST-N092 card, Vitek 2 ver. PC 3.01
Imipenem	4	4	4	8	8	8	≤1	8	≥16	4	8	≥16
Meropenem	1	1	2	1	2	1	1	1	4	1	1	2
Ertapenem	≥8	≥8	≥8	≥8	≥8	≥8	4	≥8	≥8	4	≥8	≥8
Carbapenemase	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes

^*Vitek 2 expert system warning for carbapenemase production as recognized by the phenotype.