Table 2.
Effects of Aging on the Distribution of Lymphocyte Subtypesa
|
Young elderly (65–85) |
Old elderly (>90) |
Young adults (25–35) |
|||
|---|---|---|---|---|---|
|
Marker |
Absoluteb |
% of young adult |
Absolute |
% of young adult |
Absoluteb |
|
Lymphocytes |
1980 ± 620 |
89.6 |
1830 ± 680c |
82.8 |
2210 ± 470 |
|
CD2+ |
1730 ± 410c |
87.4 |
1605 ± 470c |
81.1 |
1980 ± 310 |
|
CD3+ |
1510 ± 320c |
81.6 |
73.5 |
1850 ± 280 |
|
|
CD4+ |
1115 ± 260c |
89.6 |
1084 ± 290c |
87.1 |
1245 ± 190 |
|
CD8+ |
460 ± 190c |
68.7 |
405 ± 220c |
60.5 |
670 ± 145 |
|
CD4+:CD8+ ratio |
2.42 |
130.8 |
2.68 |
144.9 |
1.85 |
|
CD45RA (naive) |
560 ± 180c |
45.5 |
30.9 |
1230 ± 340 |
|
|
CD45RO (memory) |
1090 ± 420c |
143.4 |
1125 ± 470c |
148.0 |
760 ± 235 |
|
CD57 (NK) |
390 ± 180c |
185.7 |
430 ± 205c |
204.7 |
210 ± 135 |
Adapted from Lesourd (1999).
Absolute values are per cubic millimeter.
Significantly different from young adults.
Significantly different from young elderly.
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