Table 1.

Immunoglobulin and Other Immunoreceptor Folds

Protein/complex	Domain/region	Folda	PDBb	References
Immunoglobulins
Antibodies			1igt	Harris et al. (1997)
	Variable region	V‐ type
	Constant region	C1‐type
Major histocompatibility complexes
MHC class I			2clr	(Bjorkman et al., 1987; Collins et al., 1994b)
	Heavy chain α1+α2 domain	MHC
	Heavy chain α3 domain	C1‐type
	β2‐microglobulin	C1‐type
MHC class II			1aqd	Brown et al. (1993)
	Heavy chain α1+β1 domain	MHC
	α chain, C‐terminal domain	C1‐type
	β chain, C‐terminal domain	C1‐type
Cell surface immunoglobulin‐like receptors
T‐cell receptor, αβ type			1ao7	Garboczi et al. (1996)
	Vα, Vβ domains	V‐type
	Cβ domain	C1‐type
CD8, T‐cell coreceptor		V‐type	1cd8	Leahy et al. (1992a)
Neonatal Fcγ receptor			1fru	Burmeister et al. (1994)
	Heavy chain α3 domain	C1‐type
	β chain	C1‐type
Growth hormone receptor
	Domains 1 and 2	C2(Fn)	3hhr	de Vos et al. (1992)
EPO receptor		C2(Fn)	1ern	Livnah et al. (1999)
Prolactin receptor
	Domains 1 and 2	C2(Fn)	1bp3	Somers et al. (1994)
IFN‐γ receptor		C2(Fn)	1fg9	Walter et al. (1995)
FGFR2		I‐C2	1e0o	Pellegrini et al. (2000)
GCSFR		C2(Fn)	1cd9	Aritomi et al. (1999)
IL‐10R		C2(Fn)	1j7v	Josephson et al. (2001)
IL‐4R		C2(Fn)	1iar	Hage et al. (1999)
Gp130 receptor		C2(Fn)	1i1r	Chow et al. (2001)
CD4, T‐cell surface glycoprotein			3cd4	Ryu et al. (1990) Wang et al. (1990)
	Domains 1 and 3	V‐typec
	Domains 2 and 4	C2‐like
Fcγ receptor, type III		C2‐like	1fnl	Zhang et al. (2000)
Fcγ receptor, types IIA and IIB		C2‐like	1fcg	Maxwell et al. (1999)
Fcɛ receptor, type I		C2‐like	1f2q	Garman et al. (1998)
Coagulation factor
Tissue factor	Ectodomain	C2(Fn)	2hft	Muller et al. (1996)
Cell matrix and adhesion proteins
Fibronectin	Type III domain	C2(Fn)	1fna	Main et al. (1992)
Tenascin, repeats		C2(Fn)	1ten	Leahy et al. (1992b)
CD2			1hnf	Jones et al. (1992)
	Adhesion domain	V‐type
	C‐terminal domain	C2 like
VCAM‐1			1vca	Jones et al. (1995)
	Domain 1	I‐type
	Domain 2	C2 like
Cadherind		C1 type	1nci	Shapiro et al. (1995)
Muscle proteins
Telokin		I‐type	1tlk	Holden et al. (1992)
Titin		I‐type	1tnm	Pfuhl and Pastore (1995)
Transcription factors e
NF‐κB, p50 subunit			1nfk	Ghosh et al. (1995), Muller et al. (1995)
	First Rel homology domainf	E‐type	1svc	Muller et al. (1995)
	Second Rel homology domain	E‐type
Enzymes with immunoglobulin‐like domains
Chaperone protein, papD			3dpa	Holmgren and Branden (1989)
	Domain 1g	C2
	Domain 2h	C2
Oxidoreductase
Cu, Zn superoxide dismutasei		C2	2sod	Richardson et al. (1976)
Galactose oxidase	C domain	E‐type	1gof	Ito et al. (1991)
Transferase
Cyclodextrin glycosyltransferase		E‐type	1cdg	Lawson et al. (1994)
Lyase
Chitinase A	N‐terminal domain	E‐type	1ctn	Perrakis et al. (1994)
C‐type lectin‐like receptors
Mannose binding protein (MBP)		CTLR	1msb	Weis et al. (1991)
CD94		CTLR	1b6e	Boyington et al. (1999)
Ly48A		CTLR	1qo3	Tormo et al. (1999)
NKG2D		CTLR	1hq8	Wolan et al. (2001)
DC‐SIGN		CTLR	1k9j	Feinberg et al. (2001)
Immunoreceptor‐ligand complexes
A6 TCR/HLA‐A2(Tax)		TCR‐MHC	1ao7	Garboczi et al. (1996)
2C TCR/H‐2Kb(dEV8)		TCR‐MHC	2ckb	Garcia et al. (1998)
CD8/HLA‐A2		CD8/MHC‐I	1akj	Gao et al. (1997)
CD4/I‐A(k)		CD4/MHC‐II	1jl4	Wang et al. (2001)
B7‐1/CTLA‐4		B7/CTLA‐4	1i84	Stamper et al. (2001)
KIR2DL2/HLA‐Cw3		KIR/HLA	1efx	Boyington et al. (2000)
KIR2DL1/HLA‐Cw4		KIR/HLA	1im9	Fan et al. (2001)
NKG2D/MICA		NKG2D/ligand	1hyr	Li et al. (2001)
NKG2D/ULBP3		NKG2D/ligand	1kcg	Radaev et al. (2001b)
NKG2D/Rae‐1b		NKG2D/ligand	1jsk	Li et al. (2002b)
FcɛRI/Fc		FcR/Fc	1f6a	Garman et al. (2000)
FcγRIII/Fc		FcR/Fc	1iis, 1iix, 1e4k	Radaev et al. (2001a), Sondermann et al. (2000)
MHC‐like molecules
HLA‐A2		MHC	2clr	Bjorkman et al. (1987)
HLA‐Aw6B		MHC	1hsb	Garrett et al. (1989)
HLA‐B27		MHC	1hsa	Madden et al. (1992)
H‐2Kb		MHC	1vac	Fremont et al. (1992), Zhang et al. (1992)
HLA‐DR1		MHC	1aqd	Brown et al. (1993), Stern et al. (1994)
Neonatal Fc receptor		MHC	1fru	Burmeister et al. (1994)
HLA‐DM		MHC	1k8i	Fremont et al. (1998)
HLA‐E		MHC	1mhe	O'Callaghan et al. (1998)
CD1		MHC	1cd1	Zeng et al. (1997)
Zinc α‐2‐glycoprotein (Zag)		MHC	1zag	Sanchez et al. (1999)
MIC‐A		MHC	1b3j	Li et al. (1999)
T22		MHC	1c16	Wingren et al. (2000)

^aSee Proteins Involved in the Function of Immune Systems for explanations of folds.

^bsee Web‐Based Structural Bioinformatics and http://www.rcsb.org/pdb.

^cStrand A pairs with strand G only.

^dStrand A pairs with strand G instead of B.

^eSee also Table 6.

^fInsertion strands between strands C and C′, and E and F.

^gStrand A pairs with both B and G.

^hOne additional strand at C terminus.

ⁱOne additional strand at N terminus.

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