Table 4.

Modular Domains Involved In Signal Transduction

Protein	PDB entrya	References
Domains that bind phosphotyrosine
SH2 domains
v‐src tyrosine kinase SH2 domain	1sha	Waksman et al. (1992)
p85 α subunit of PI 3‐kinase SH2	2pnb	Booker et al. (1992)
C‐abl SH2 domain	1ab2	Overduin et al. (1992)
PTB domains
Shc PTB domain	1shc	Zhou et al. (1995)
IRS‐1 PTB domain	1irs	Eck et al. (1996), Zhou et al. (1996)
Phosphoserine and phosphothreonine binding domains
FHA domains
RAD53 FHA domain	1g6g, 1dmz	Liao et al. (1999), Durocher et al. (2000)
14‐3‐3 domains
14‐3‐3 ζ	1a40	Liu et al. (1995)
14‐3‐3 τ	—	Xiao et al. (1995)
Polyproline binding domains
SH3 domains
α Spectrin SH3 domain	1shg	Musacchio et al. (1992)
Chicken c‐src SH3 domain	1rlp	Yu et al. (1992)
p85 α subunit of PI 3‐kinase SH3	2pni	Booker et al. (1993)
ww domains
Kinase associated protein WW	—	Macias et al. (1996)
Distrophin WW domain	1eg4	Huang et al. (2000)
EVH1 domains
Murine enabled EVH1 domain	1evh	Prehoda et al. (1999)
Murine ena/vasp‐like EVH1 domain	1qc6	Fedorov et al. (1999)
GYF domains
Drosophila CD2BP2 GYF domain	1gyf	Freund et al. (1999)
Phospholipid binding domains
PH domains
Dynamin PH domain	1dyn	Downing et al. (1994), Ferguson et al. (1994)
β‐spectrin PH domain	1btn	Macias et al. (1994)
Pleckstrin PH domain	1pls	Yoon et al. (1994)
C1 domains
Rat protein kinase C‐γ C1 domain	—	Hommel et al. (1994)
Rat protein kinase C‐δ C1 domain	1ptq	Zhang et al. (1995)
C2 domains
Synaptotagmin I C2 domain	I1rsy	Sutton et al. (1995)
Phospholipase C‐δ C2 domain	1qas	Grobler et al. (1996)
Protein kinase C‐α C2 domain	1dsy	Verdaguer et al. (1999)
FYVE domains
Hrs FYVE domain	1dvp	Mao et al. (2000)
Vps27p FYVE domain	1vfy	Misra and Hurley (1999)
Eea1 FYVE domain	1joc	Dumas et al. (2001)
Protein interaction domains
PDZ domains
PSD‐95 third PDZ domain	1be9, 1bfe	Doyle et al. (1996)
Dlg third PDZ domain	1pdr	Morais Cabral et al. (1996)
VHS domains
Hrs VHS domain	1dvp	Mao et al. (2000)
Tom1 VHS domain	1elk	Misra et al. (2000)
GGA1 VHS domain	1jwg, 1jwf	Shiba et al. (2002)
GGA3 VHS domain	1juq, 1jpl	Misra et al. (2002)
SNARES
Syntaxin‐1A/synaptobrevin‐II/SNAP‐25B	1sfc	Sutton et al. (1998)
SAM domains
EphB2 receptor SAM domain	1b4f, 1sgg	Smalla et al. (1999), Thanos et al. (1999)
EphA4 receptor SAM domain	1b0x	Stapleton et al. (1999)
Polyhomeotic SAM domain	1kw4	Kim et al. (2002)
MH2 domains
Smad2 MH2 domain	1dev	Wu et al. (2000)
Smad3 MH2 domain	1mk2	Qin et al. (2002)
Structural repeat motifs
Leucine rich repeats (LRRs)
Ribonuclease inhibitor	2bnh	Kobe and Deisenhofer (1993)
Ribonuclease inhibitor/RNAse A	1dfj	Kobe and Deisenhofer (1995)
Internalin B	1d0b	Marino et al. (1999)
RanGAP protein rna1p	1yrg	Hillig et al. (1999)
HEAT repeats
Protein phosphatase 2A PR65/A subunit	1b3u	Groves et al. (1999)
Karyopherin 2/Ran‐GppNHp complex	1qbk	Chook and Blobel (1999)
Armadillo (ARM) repeats
Karyopherin α	1bk5, 1bk6	Conti et al. (1998)
β‐catenin	3bct	Huber et al. (1997)
β‐catenin bound to E‐cadherin	1i7w	Huber and Weis (2001)
Ankyrin (ANK) repeats
GABPβ	1awc	Gorina and Pavletich (1996)
p16INK4a bound to Cdk6	1bi7	Russo et al. (1998)
IκBα/NF‐κB complex	1ikn	Huxford et al. (1998)

^asee Web‐Based Structural Bioinformatics and http://www.rcsb.org/pdb. For proteins with no entry listed, coordinates have not been deposited in the Protein Data Bank.

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