Table 5.

Kinases and Phosphatases

Protein	PDB entrya	References
Protein kinases
Protein tyrosine kinases
Tyrosine kinase C‐src	1fmk	Xu et al. (1997a)
Lymphocyte cell kinase (lck)	3lck	Yamaguchi and Hendrickson (1996)
Haematopoietic cell kinase (hck)	1ad5	Sicheri et al. (1997)
C‐terminal src kinase	1byg	Lamers et al. (1999)
Tie2 protein tyrosine kinase	1fvr	Shewchuk et al. (2000)
Human insulin receptor kinase	1irk	Hubbard et al. (1994)
Insulin‐like growth factor‐1 receptor	1k3a	Favelyukis et al. (2001)
FGF receptor‐1	1fgk	Mohammadi et al. (1996)
EPHB2 receptor	1jpa	Wybenga‐Groot et al. (2001)
Vascular growth factor receptor‐2	1vr2	McTigue et al. (1999)
Protein serine/threonine kinases
Cyclic AMP kinases	1atp	Knighton et al. (1991), Olah et al. (1993)
Cyclin‐dependent kinase 2	1bi7	De Bondt et al. (1993), Jeffrey et al. (1995)
Cyclin A‐CDK	1fin	Jeffrey et al. (1995)
Cell cycle protein CksHs1	1dks	Arvai et al. (1995)
MAP kinase ERK2	1gol	Zhang et al. (1994)
MAP kinase p38	1p38	Wang et al. (1997)
Phosphorylase kinase	1phk	Owen et al. (1995)
Calcium/calmodulin‐dependent kinase	1ao6	Goldberg et al. (1996)
Twitchin kinase	1koa	Hu et al. (1994)
Casein kinase I	1cki	Xu et al. (1995)
Death associated protein kinase	1jks	Tereshko et al. (2001)
Phosphatases
Protein tyrosine phosphatases
Subtype I
Low molecular weight	1phr	Su et al. (1994)
Subtype II
High molecular weight
PTB1	2hnq	Barford et al. (1994)
SHP‐1	1gwz	Yang et al. (1998)
SHP‐2	2shp	Hof et al. (1998)
Yersinia PTP	1ypt	Stuckey et al. (1994)
SptP tyrosine phosphatase domain	1g4u	Stebbins and Galan (2000)
RPTP LAR tandem phosphatase	1lar	Nam et al. (1999)
Dual specificity
VHR	1vhr	Yuvaniyama et al. (1996)
Kinase associated phosphatase (kap)	1fpz	Song et al. (2001)
MAP kinase phosphatase	1mkp	Stewart et al. (1999)
PTEN tumor suppressor	1d5r	Lee et al. (1999)
Third subtype
CDC25A	1c25	Fauman et al. (1998)
ERK2 binding domain of MKP‐3	1hzm	Farooq et al. (2001)
Protein serine/threonine phosphatases
PPP family enzymes
PP1	1fjm	Goldberg et al. (1995)
Calcineurin	1aui	Kissinger et al. (1995)
Bacteriophage λ phosphatase	1g5b	Voegtli et al. (2000)
Purple acid phosphatase	1kbp	Strater et al. (1995)
UDP sugar hydrolase	1ush	Knofel and Strater (1999)
MRE11 nuclease	1ii7	Hopfner et al. (2001)
PPM family
Protein phosphatase 2C	1a6q	Das et al. (1996)
Alkaline phosphatase fold
Alkaline phosphatase	1ali	Kim and Wyckoff (1991)
Arylsulfatase	1auk	Lukatela et al. (1998)
Prokaryotic cofactor‐independent phosphoglycerate mutase	1eqj	Jedrzejas et al. (2000)
Sugar phosphatases
Fructose 1,6‐biosphastase	5fbp	Ke et al. (1991)
Inositol monophosphatase	2hhm	Bone et al. (1992)
Inositol polyphosphate 1‐phosphatase	1inp	York et al. (1994)
3,5‐adenosine bisphosphatase	1qgx	Albert et al. (2000)
PIPase	1jp4	Patel et al. (2002)
The cyclin fold
Cyclin A	1fin	Jeffrey et al. (1995)
Transcription factor IIB	1vol	Nikolov et al. (1995)
Retinoblastoma tumor suppressor protein	1gux	Lee et al. (1998)

^aSee Web‐Based Structural Bioinformatics and http://www.rcsb.org/pdb.

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