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. 2020 Apr 16;15(4):e0231707. doi: 10.1371/journal.pone.0231707

Table 4. Index of additive biological interactive effect of high sodium intake and increased triglyceride level on hypertension.

Unadjusted Adjusted*
Measure Estimate 95% CI Estimate 95% CI
RERI 0.051 0.045–0.056 0.008 0.002–0.014
AP 0.038 0.017–0.058 0.015 0.008–0.022
SI 1.168 1.052–1.284 1.119 1.101–1.137

*Adjusted for age, sex, smoking history, body mass index, waist circumference, white blood cell count, hemoglobin, fasting plasma glucose, hemoglobin A1c, aspartate aminotransferase, alanine aminotransferase, UACR, and daily alcohol intake.

If there was no biological interaction, the 95% CI of RERI and AP included 0, and the 95% CI of SI contained 1.

RERI, the relative excess risk because of the interaction; AP, the attributable proportion of the interaction; SI, the additive interaction index of synergy.