TABLE 2.

Severe hypoglycemia (SH) rate per 100 patient years (95%CI) adjusted for gender, age group and duration of diabetes and incidence rate ratio (IRR) (95%CI) by registry and HbA1c category

HbA1c (%) category		<7%	7% to <8%	8% to <9%	≥9%
DPV	No. cases	4,335	6,734	4,477	3,241
	No. SH events	167 (113, 54)	242	215	94
	SH rate	3.3 (2.7–4.0)	3.2 (2.7–3.7)	4.2 (3.5–5.0)	2.5 (1.9–3.1)
	IRR	1.05 (0.82–1.34)	1.00	1.32 (1.05–1.67)*	0.78 (0.58–1.04)
T1DX	No. cases	474	2,126	2,363	162
	No. SH events	33	113	162	195
	SH rate	6.6 (4.2–10.6)	5.1 (4.0–6.5)	6.9 (5.6–8.5)	8.7 (7.1–10.7)
	IRR	1.30 (0.77–2.18)	1.00	1.34 (0.98–1.84)	1.70 (1.24–2.32)†
WACDD	No. cases	90	357	231	187
	No. SH events	6	27	16	17
	SH rate	4.7 (1.7–12.8)	5.4 (3.3–8.9)	5.8 (3.2–10.7)	9.0 (4.8–16.8)
	IRR	0.87 (0.29–2.60)	1.00	1.08 (0.50–2.34)	1.67 (0.74–3.78)

Abbreviations: DPV, Diabetes Patienten Verlaufsdokumenation; HbA1c, glycated hemoglobin; T1DX, Type 1 Diabetes Exchange; WACDD, Western Australian Children Diabetes Database.

^*P = .02,

^†P = .001.