TABLE 3.

Severe hypoglycemia (SH) rate per 100 patient years (95%CI) adjusted for gender, age group and duration of diabetes and incidence rate ratio (IRR) (95%CI) by treatment regimen, registry, and HbA1c category

PATIENTS TREATED BY CSII
HbA1c (%) category		<7%	7% to <8%	8% to <9%	≥9%
DPV	No. cases	2,512	3,676	2,647	2,197
	SH rate	2.6 (1.9–3.6)	2.3 (1.8–3.0)	2.8 (2.1–3.8)	2.3 (1.5–3.6)
	IRR	1.15 (0.77–1.73)	1.00	1.22 (0.82–1.83)	1.01 (0.61–1.68)
T1DX	No. cases	143	624	897	1,214
	SH rate	6.8 (4.0–11.8)	5.2 (3.9–6.9)	4.9 (3.2–7.7)	8.4 (6.1–11.4)
	IRR	1.31 (0.71–2.42)	1.00	0.95 (0.64–1.42)	1.61 (1.06–2.44)*
WACDD	No. cases	45	211	157	149
	SH rate	6.9 (2.0–2.4)	3.5 (1.4–8.4)	3.6 (1.0–13.0)	5.6 (0.1–28.3)
	IRR	1.99 (0.43–9.13)	1.00	1.03 (0.22–4.88)	1.61 (0.25–10.24)
PATIENTS TREATED BY INJECTIONS
HbA1c (%) category		<7%	7% to <8%	8% to <9%	≥9%
DPV	No. cases	1,823	3,058	1,830	1,044
	SH rate	3.8 (3.0–4.9)	3.9 (3.2–4.7)	5.1 (4.1–6.3)	2.5 (1.9–3.4)
	IRR	0.99 (0.73–1.38)	1.00	1.32 (0.99–1.76)	0.66 (0.46–0.93)†
T1DX	No. cases	331	1,502	1,466	925
	SH rate	6.1 (2.6–14.4)	4.9 (3.9–6.9)	10.1 (7.4–13.7)	8.9 (6.8–11.6)
	IRR	1.23 (0.47–3.25)	1.00	2.05 (1.20–3.51) ‡	1.80 (1.08–3.02)*
WACDD	No. cases	45	146	74	38
	SH rate	2.8 (0.6–14.3)	0.7 (3.7–12.1)	6.8 (3.4–13.6)	1.0 (5.0–19.3)
	IRR	0.42 (0.08–2.30)	1.00	1.02 (0.42–2.50)	1.47 (0.59–3.68)

Abbreviations: DPV, Diabetes Patienten Verlaufsdokumenation; HbA1c, glycated hemoglobin; T1DX, Type 1 Diabetes Exchange; WACDD, Western Australian Children Diabetes Database.

^*P = .03,

^†P = .02,

^‡P = .009.