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. 2020 Apr 16;15(4):e0231711. doi: 10.1371/journal.pone.0231711

Fig 6. The reciprocal expression of AnxA6 and GRF2 delineates rapidly growing basal-like from invasive mesenchymal-like TNBC cell lines.

Fig 6

A) Whole cell extracts were prepared from TNBC cell lines (n = 19) and normal breast epithelial cells (n = 2). The blots were analyzed by western blotting and densitometry as recently reported in Whalen et al., 2019 (Ref. 17). The ratio of GRF2:AnxA6 was used to stratify the cell lines according to their potential for rapid growth or invasiveness. B) A plot of the reciprocal expression of AnxA6 and GRF2 delineating TNBC cells with a higher potential for rapid growth (low AnxA6/high GRF2) from those with a higher potential for invasiveness (high AnxA6/low GRF2). C) A heat map of cells from Group 1 (n = 4) and Group 3 (n = 5) showing the clustering of the TNBC cell lines from each group and the discernible differences in their gene expression profiles.