Fig 8. Distinct phenotypes of AnxA6 expressing and AnxA6 down regulated TNBC cells.

Schematic showing 3D cultures in growth factor-reduced matrigel and the transformation of the AnxA6-high/GRF2-low invasive BT-549 TNBC cells into AnxA6-low/GRF2-high rapidly growing BT-549 TNBC cells following down regulation of AnxA6. It should be noted that parental BT-549 cells are poorly tumorigenic while AnxA6 depletion or loss in BT-549 leads to high tumorigenicity (see Ref. 17).