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. 2020 Apr 6;16(4):e1008242. doi: 10.1371/journal.ppat.1008242

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© 2020 Graziano et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) Cd300lf^+/+Stat1^-/- (N = 8) and Cd300lf^+/-Stat1^-/- (N = 4) mice challenged with 10⁶ PFU PO MNoV^CW3 succumbed to infection by 5 and 6 dpi, respectively. In contrast, all Cd300lf^-/-Stat1^-/- (N = 10) mice survived for at least 21 dpi. (B-F) Cd300lf^+/+Stat1^-/-, Cd300lf^+/-stat1^-/-, and Cd300lf^-/-Stat1^-/- mice were challenged with 10⁶ PFU PO MNoV^CR6. All mice survived infection. Viral genomes were quantified in the (B) feces, (C) MLN, (D) spleen, (E) ileum, and (F) colon at seven dpi. Data is pooled from at least three independent experiments. Data was analyzed by Mann-Whitney test and Kaplan-Meier curves were generated for survival experiments. Shown are means ± SEM. NS, not significant; *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. L.O.D., limit of detection.