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. 2020 Apr 6;16(4):e1008242. doi: 10.1371/journal.ppat.1008242

Fig 5. CD300lf is essential for pathogenesis of parenterally transmitted MNoV in STAT1 deficient mice.

Fig 5

(A) Mice were challenged with 107 PFU IP MNoVCW3. Cd300lf-/-Stat1-/- mice (N = 9 mice) survived infection in contrast to Cd300lf+/+Stat1-/- (N = 15 mice) and Cd300lf+/-Stat1-/- (N = 9 mice) littermates. (B) Mice were challenged with 107 PFU IP MNoVCR6. Cd300lf-/-Stat1-/- mice (N = 6 mice) survived infection in contrast to Cd300lf+/+Stat1-/- (N = 9 mice) and Cd300lf+/-Stat1-/- (N = 3 mice) littermates. (C) MNoV genomes were quantified from the MLN, spleen, ileum, and colon of Cd300lf-/-Stat1-/- mice seven days post-challenge with 107 PFU IP MNoVCR6. Data was analyzed by Kaplan-Meier curve for survival experiments. Data is pooled from at least three independent experiments with 1–5 mice per group. *P<0.05; **P<0.01; ***P<0.001; ****P<0.0001. L.O.D., limit of detection.