Figure 2. Mapping of 62 brain-aging modes and 6 mode-clusters onto different classes of strucural and functional imaging-derived phenotypes (IDPs).

Above: Each row shows the mapping of one brain-aging mode onto the imaging data, with black lines delineating groups of 10 modes for ease of reference. The full plots spanning all 3913 IDPs are shown in Figure 2—figure supplement 1; here, each class of IDPs is reduced using PCA and then ICA to the most representative pseudo-IDPs (see Materials and methods), meaning that each column in the plot relates to a fixed and distinct combination of original IDPs. IDP classes have fewer/greater distinct values here dependent on the number of IDPs in a class, and how highly they correlate with each other. Colour-coded values shown are unitless and mapped into the range −1:1. Below: The equivalent (separately computed) summary figure mapping the 6 mode-clusters onto IDPs.

Figure 2—figure supplement 1. Mapping of brain-aging modes and mode-clusters onto individual IDPs.

See Materials and methods for details, and Data availability for the complete listing of IDPs (x axis) and tables listing the strongest weights from these mappings. See Figure 2 for a simpler, more interpretable summary of this, where the x axis is reduced to different classes of IDPs.

Figure 2—figure supplement 2. Histogram of proportions of subjects of (non-missing) data for each nIDP (non-imaging-derived phenotypes).

nIDPs are not retained if fewer than 40 subjects have data present.