Figure 4.

Example of an engineered bispecific antibody–10E8.4/iMab represented on the left. See text for details. Adapted from Huang et al.²³

• One arm of IgG binds an epitope in the membrane proximal external region (MPER) of gp41
• The other arm binds either the HIV-1 CD4 receptor on T-helper cell

Phase 1, first in human, clinical study for treatment and prevention is starting 2019