. Author manuscript; available in PMC: 2021 Apr 3.

Published in final edited form as: J Proteome Res. 2020 Feb 27;19(4):1635–1646. doi: 10.1021/acs.jproteome.9b00840

Table 4.

Selected Deleterious SAAVs from Predicted 79 Deleterious SAAVs Based on the AssVar Server^a

protein name	gene name	accession number	mutation position	wild-type AA	mutant-type AA	impact score	prediction results
glucose-6-phosphate exchanger SLC37A4	SLC37A4	O43826	88	G	D	0.91	1^b
GTPase Hras	HRAS	P01112	61	Q	E	0.88	1
GTPase Kras	KRAS	P01116	22	Q	E	0.87	1
GTPase Kras	KRAS	P01116	12	G	D	0.95	1
GTPase Kras	KRAS	P01116	12	G	R	0.94	1
cellular tumor antigen p53	TP53	P04637	273	R	H	0.87	1
aldehyde dehydrogenase, mitochondrial	ALDH2	P05091	287	G	A	0.91	1
insulin receptor	INSR	P06213	1055	A	V	0.86	1
annexin A11	ANXA11	P50995	230	R	C	0.69	1^c
neuroblast differentiation-associated protein AHNAK	AHNAK	Q09666	4090	D	G	0.78	1
activating signal cointegrator 1 complex subunit 3	ASCC3	Q8N3C0	1995	S	C	0.63	1^c
nuclear pore membrane glycoprotein 210	NUP210	Q8TEM1	1052	G	S	0.89	1
HEAT repeat-containing protein 1	HEATR1	Q9H583	2017	E	G	0.68	1^c
NSFL1 cofactor p47	NSFL1C	Q9UNZ2	290	D	N	0.58	1^c
ADP-ribosylation factor-like protein 5 A	ARL5A	Q9Y689	125	N	S	0.86	1
filamin-A	FLNA	P21333	207	P	L	0.74	1
filamin-A	FLNA	P21333	605	D	N	0.62	1
integrin α−6	ITGA6	P23229	419	A	T	0.58	1^c

All 79 deleterious SAAVs are shown in Supporting Information Table S2.

Prediction results “1” refer to the deleterious SAAV.

Superscript “c” means it is common to three different database searching methods. A total of five deleterious SAAVs were shared by three strategies.