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. Author manuscript; available in PMC: 2020 Apr 16.
Published in final edited form as: Virus Res. 2013 Dec 25;182:5–20. doi: 10.1016/j.virusres.2013.12.017

Fig. 4. BTV cell attachment.

Fig. 4

(A) The model of cell surface interaction of VP2. The side on profile of a VP2 triskelion trimer is shown. Two VP2 molecules can be seen (green and purple) attached to an underlying VP7 trimer (red). Note the L shaped profile of the trimer. The hub domain binds a sialidated cell surface protein (green) in a receptor pocket. The tip domain may interact with an additional co-receptor (purple). (Adapted from Zhang et al., 2010). (B) Sialic acid interaction is necessary but not sufficient for cell entry. Pre-treatment of HeLa cells with wheat germ agglutinin (lectin) drastically decreases but does not inhibit the replication of BTV.