Table 1. The proteins encoded by BTV segments and their functions (sizes for BTV serotype 10, modified from Roy, 2001).
| Segment (size in base pairs | Protein/s encoded (size in kilo Daltons) | Protein function |
|---|---|---|
| S1 (3944) | VP1 (150kDa) | RNA dependent RNA polymerase |
| S2 (2926) | VP2 (111 kDa) | Receptor binding and cell entry |
| S3 (2772) | VP3 (103 kDa) | Sub-core structural protein, localises viral polymerase complex |
| S4 (2011) | VP4 (76 kDa) | Capping enzyme |
| S5 (1769) | NS1 (64 kDa) | Viral protein translation enhancer |
| S6 (1638) | VP5 (59 kDa) | Membrane permeabilization protein |
| S7 (1156) | VP7 (38 kDa) | Core structural protein and receptor binding protein for Culicoides cells |
| S8 (1124) | NS2 (42 kDa) | Concentrator of core components, viral inclusion body formation |
| S9 (1046) | VP6 (36 kDa) NS4 (17 kDa) |
Viral fitness to interferon response |
| S 10 (822) | NS3 (26 kDa) NS3A (25 kDa) |
Adaptor protein facilitating egress |