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Table 3.

Comparison of LYG with polymorphic PTLD and EBV+ DLBCL

LYG Polymorphic PTLD EBV+ DLBCL
Clinical features Immunodeficient state often unknown Immunodeficient state known Often immunocompetent, but immune senescence plays a role
Extranodal involvement frequent, most commonly lung, CNS, and skin Extranodal involvement frequent, most commonly gastrointestinal, lung, CNS, kidney, heart and liver, including the allograft Extranodal involvement less common and involving diverse sites
Lymph node and/or bone marrow involvement extremely rare Lymph node involvement uncommon and bone marrow disease rare Lymph node involvement common and bone marrow disease uncommon
Pathologic features EBV+ atypical B cells in a T-cell rich background EBV+ atypical B cells predominate EBV+ atypical B cells predominate
Angiocentric and angioinvasive polymorphous infiltrate present Polymorphous plasma cell-rich infiltrate present but typically not angiocentric or angioinvasive EBV+ large B cells predominate
Various degrees of coagulative necrosis Coagulative necrosis may be present Various degrees coagulative necrosis
EBV viral load Often low to negative Often significantly elevated Often significantly elevated