Table 3.

Comparison of LYG with polymorphic PTLD and EBV⁺ DLBCL

	LYG	Polymorphic PTLD	EBV+ DLBCL
Clinical features	Immunodeficient state often unknown	Immunodeficient state known	Often immunocompetent, but immune senescence plays a role
	Extranodal involvement frequent, most commonly lung, CNS, and skin	Extranodal involvement frequent, most commonly gastrointestinal, lung, CNS, kidney, heart and liver, including the allograft	Extranodal involvement less common and involving diverse sites
	Lymph node and/or bone marrow involvement extremely rare	Lymph node involvement uncommon and bone marrow disease rare	Lymph node involvement common and bone marrow disease uncommon
Pathologic features	EBV+ atypical B cells in a T-cell rich background	EBV+ atypical B cells predominate	EBV+ atypical B cells predominate
	Angiocentric and angioinvasive polymorphous infiltrate present	Polymorphous plasma cell-rich infiltrate present but typically not angiocentric or angioinvasive	EBV+ large B cells predominate
	Various degrees of coagulative necrosis	Coagulative necrosis may be present	Various degrees coagulative necrosis
EBV viral load	Often low to negative	Often significantly elevated	Often significantly elevated