Table 3.

Associations between individual biomarkers with radiographic disc space narrowing in unadjusted, propensity score matched models and matched and adjusted models.

Biomarker	Unadjusted Risk Ratio (95% CI)	Matched* Risk Ratio (95% CI)	Matched and Adjusted** Risk Ratio (95% CI)
Structural Biomarkers
N-Cadherin,	0.68 (0.17, 2.75)	1.35 (0.36, 5.10)	1.27 (0.28, 5.91)
Keratin-19	0.95 (0.44, 2.02)	1.74 (0.78, 3.86)	1.65 (0.73, 3.73)
Lumican	1.52 (0.51, 4.57)	1.27 (0.36, 4.47)	1.18 (0.34, 4.07)
Inflammatory Biomarkers
OPG	3.43 (1.60, 7.32)	4.41 (2.69, 7.24)	3.90 (1.83, 8.31)
IL-17	0.36 (0.04, 3.54)	0.20 (0.02, 2.20)	0.21 (0.02, 2.12)
CXCL6	0.20 (0.02, 2.29)	0.46 (0.03, 6.61)	0.50 (0.04, 6.86)
RANTES	0.48 (0.15, 1.51)	0.70 (0.21, 2.30)	0.71 (0.22, 2.30)
IL-6	2.32 (1.78, 3.05)	2.45 (1.89, 3.23)	2.54 (1.92, 3.36)
Pain Biomarkers
BDNF	0.45 (0.15, 1.39)	0.62 (0.21, 1.83)	0.68 (0.22, 2.07)
NPY	2.12 (1.68, 2.68)	2.12 (1.68, 2.69)	2.06 (1.62, 2.63)
Pain Measure
Pressure Pain Threshold	1.53 (0.96, 2.44)	0.99 (0.59, 1.65)	1.00 (0.60, 1.66)

^*Matched for age, sex, knee OA, hip OA

^**Matched for age, sex, knee OA, hip OA and Adjusted for Depressive Symptoms via CES-D score. Bold items are statistically significant