. Author manuscript; available in PMC: 2021 Nov 1.

Published in final edited form as: Clin Gastroenterol Hepatol. 2019 Oct 17;18(12):2760–2767.e12. doi: 10.1016/j.cgh.2019.10.021

Appendix Table 2.

Natural History adjustments for the Lynch Syndrome population.

Parameter	Value (Range^a)	Source
Probability of having developed colorectal cancer before age 80	42% (30-60%)	¹
Dwelling times, faster progression compared to the general population	10x (0x/2x/5x/20x)^b	Assumption
Hazard Ratio overall survival of CRC in LS cases versus CRC in the general population	0.65 (0.59-0.71)	¹⁷

CRC= Colorectal cancer, LS= Lynch Syndrome

^a.

Alternative values evaluated in sensitivity analyses.

^b.

In the Probabilistic Sensitivity Analysis, 0x, 2x, 5x, 10x and 20x faster dwelling times were evenly incorporated.