Appendix Table 5.
Number of individuals and associated costs per 1000 CRC index cases in every step of the patient flow diagram.
| Step in patient flow diagram | No. of individuals | Costs ($)a |
|---|---|---|
| LS testing of index CRC cases | ||
| Immunohistochemistry MLH1, MSH2/6, PMS2 | 1000 | 150,000 |
| BRAF V600E mutation | 133 | 39,900 |
| Methylation MLH1 promoter | 85 | 34,000 |
| Total | 223,900 | |
| Index Case Genetic Pathway | ||
| Patient navigator | 45 | 4,848 |
| Pre-germline testing counseling | 38 | 9,639 |
| Germline testing | 30 | 33,234 |
| Positive cases: post-germline testing counseling | 20 | 1,796 |
| Negative cases: somatic testing | 10 | 5,141 |
| Total | 54,658 | |
| First-Degree Relatives Pathway | ||
| FDRs of LS positive CRC index cases | 119 | |
| Pre-germline testing counseling | 62 | 5,567 |
| Germline testing | 59 | 23,505 |
| Post-germline testing counseling | 29 | 2,644 |
| Total | 31,716 | |
| Total | 310,274 |
CRC=Colorectal cancer, FDR= First-degree relatives, LS= Lynch syndrome
a.
Costs are in 2018 Canadian Dollars.