Table 2.
Baseline hematologic and inflammatory biomarkers among Tanzanian pregnant women using conventional cutoffs
| Biomarker1 | Iron replete, received iron, N=750 | Iron replete, received placebo, N=750 | Iron deficient, received iron, N=600 | Total, N=2100 |
|---|---|---|---|---|
| Hemoglobin, n=2078 | ||||
| Median (IQR) | 116 (108, 125) | 117 (109, 124) | 102 (92, 111) | 113 (103, 121) |
| %Deficient, <110g/L | 28% | 26% | 70% | 39% |
| Ferritin, n=2077 | ||||
| Median (IQR) | 30.7 (18.9, 47.9) | 30.0 (19.3, 51.0) | 5.8 (2.9, 9.2) | 21.6 (10.9, 41) |
| %Deficient, ≤15 μg/L | 13% | 13% | 93% | 36% |
| %hID | 29% | 32% | 98% | 49% |
| %rID | 29% | 30% | 96% | 49% |
| ZPP, n=618 | ||||
| Median (IQR) | 50 (41, 68) | 52 (41, 68) | 73 (54, 101) | 57 (44, 83) |
| %Deficient, >70 mmol/L | 21% | 22% | 59% | 37% |
| Hepcidin, n=771 | ||||
| Median (IQR) | 2.2 (1.4, 4.3) | 2.0 (1.3, 4.9) | 1.0 (0.9, 1.5) | 1.4 (1.0, 2.6) |
| %Deficient, ≤13.3μg/L | 96% | 94% | 100% | 97% |
| sTfR, n=746 | ||||
| Median (IQR) | 2.0 (1.1, 2.8) | 1.9 (1.1, 2.9) | 3.4 (2.1, 4.8) | 2.5 (1.5, 3.9) |
| % Deficient, >4.4mg/L | 7% | 8% | 32% | 20% |
| CRP, n=2064 | ||||
| Median (IQR) | 4.7 (2.1, 8.3) | 4.2 (2.2, 7.8) | 3.8 (2.0, 7.0) | 4.3 (2.1, 7.7) |
| % Elevated, >8.2mg/L | 25% | 23% | 19% | 23% |
| AGP, n=975 | ||||
| Median (IQR) | 59.8 (47.1, 71.5) | 60.4 (49.2, 72.4) | 51.6 (41.4, 64.3) | 55.3 (44.5, 68.9) |
| % Elevated, >1mg/L | 100% | 100% | 94% | 97% |
1
Hemoglobin and ZPP were measured in whole blood. Ferritin, hepcidin and sTfR were measured in serum.
2
hID refers to iron deficiency determined based on the higher ferritin cutoff approach. rID refers to iron deficiency determined based on regression-correction approach.
Values are median (IQRs) or percentages.