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Study flow chart. (*) This age was chosen because the incidence of malignant mesothelioma (MM) before age 50 years is rare and suggestive of genetic predisposition or environmental exposure since childhood. ccRCC, clear-cell renal cell carcinoma; CM, cutaneous melanoma; MARF, Mesothelioma Applied Research Foundation; NYU, New York University; tNGS, targeted next-generation sequencing; UVM, uveal melanoma.
