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. 2020 Mar 25;53(4):e12800. doi: 10.1111/cpr.12800

FIGURE 1.

FIGURE 1

p75NTR−/− mice exhibit an alveolar bone loss phenotype. (A) Micro‐CT three‐dimensional images of alveolar bone in 1‐month‐old and 4‐month‐old male wild‐type (WT) and p75NTR−/− mice. Scale bar represents 2.0 mm. (B) Bone histomorphometry of the alveolar bone. Bone volume (BV), bone volume/total volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp) are shown. (C) Serum levels of calcium, phosphorus, parathyroid hormone (PTH) and calcitonin (CT) in 1‐month‐old and 4‐month‐old WT and p75NTR−/− mice. (D) mRNA and (E) protein levels of Runx2 and Col1 in 4‐month‐old WT and p75NTR−/− mice alveolar bone were detected by real‐time PCR and Western blot analysis, respectively, GAPDH were used as the reference gene. Grayscale analysis was performed, and the levels of the indicated proteins are expressed relative to the levels of GAPDH. KO represent p75NTR−/−. Data are shown as mean ± SD from three independent experiments. *P < .05, **P < .01, ***P < .001, ns = no significant difference