Table 2.

KYNA production in cancer cells in vitro

Cell type	Cell line	KYNA production	Comments	References
Human gliomas	Biopsy material	43.7 ± 12.2 pmol KYNA/mg protein/2 h	Astrocytoma (incubation with 200 μM l-KYN, 2 h)	[54]
		10.4 ± 2.5 pmol KYNA/mg protein/2 h	Glioblastoma (incubation with 200 μM l-KYN, 2 h)
Rat glioma	C6	29.7 pmol KYNA/mg protein/2 h	Incubation with 5 µM l-KYN, 5 h	[55]
Human myeloma	U266	~ 7 pmol KYNA/5 × 105 cells/2 h	Incubation with 5 µM l-KYN, 2 ha	[41]
	RPMI8226	~ 1.5 pmol KYNA/5 × 105 cells/2 h
Human colon adenocarcinoma	Caco-2	4.21 pmol/1 × 105 cells/2 h	Incubation with 5 µM l-KYN, 2 h	[24]
	HT-29	1.39 pmol/1 × 105 cells/2 h
	LS-180	1.18 pmol/1 × 105 cells/2 h

^aEstimated from graphs