Table 1.
Developmental genes from S. macrospora. References: [1] (Masloff et al. 1999), [2] (Nowrousian et al. 1999), [3] (Pöggeler and Kück 2004), [4] (Kück 2005), [5] (Mayrhofer and Pöggeler 2005), [6] (Mayrhofer et al. 2006), [7] (Nolting and Pöggeler 2006a), [8] (Nolting and Pöggeler 2006b), [9] (Pöggeler et al. 2006), [10] (Engh et al. 2007a), [11] (Engh et al. 2007b), [12] (Nowrousian et al. 2007), [13] (Kamerewerd et al. 2008), [14] (Elleuche and Pöggeler 2009), [15] (Nolting et al. 2009), [16] (Nowrousian 2009), [17] (Bloemendal et al. 2010), [18] (Klix et al. 2010), [19] (Bernhards and Pöggeler 2011), [20] (Bloemendal et al. 2012), [21] (Gesing et al. 2012), [22] (Nowrousian et al. 2012), [23] (Voigt and Pöggeler 2013a), [24] (Voigt et al. 2013), [25] (Dirschnabel et al. 2014), [26] (Lehneck et al. 2014), [27] (Schindler and Nowrousian 2014), [28] (Teichert et al. 2014b), [29] (Frey et al. 2015a), [30] (Frey et al. 2015b), [31] (Nordzieke et al. 2015), [32] (Traeger and Nowrousian 2015), [33] (Beier et al. 2016), [34] (Werner et al. 2016), [35] (Teichert et al. 2017b), [36] (Radchenko et al. 2018), [37] (Reschka et al. 2018), [38] (Schumacher et al. 2018), [39] (Lütkenhaus et al. 2019), [40] (Werner et al. 2019)
| Gene | Locus tag number | Gene product/conserved domains | Ref. |
|---|---|---|---|
| Primary metabolism and basic cellular functions | |||
| acl1 | SMAC_06775 | Subunit of the ATP citrate lyase | [2] |
| cas1 | SMAC_03420 | β-class carbonic anhydrase | [14, 26] |
| cas2 | SMAC_03614 | β-class carbonic anhydrase | [14, 26] |
| cas3 | SMAC_03179 | β-class carbonic anhydrase | [14, 26] |
| cas4 | SMAC_03821 | α-class carbonic anhydrase | [26] |
| leu1 | SMAC_07802 | β-isopropylmalate dehydrogenase | [4] |
| sec22 | SMAC_06625 | SNARE protein | [32] |
| -- | SMAC_06770 | Putative glycolipid 2-alpha-mannosyltransferase | [39] |
| Autophagy genes | |||
| Smatg4 | SMAC_08321 | Cysteine protease | [23] |
| Smatg7 | SMAC_06539 | E1-like enzyme | [15] |
| Smatg8 | SMAC_02305 | Ubiquitin-like protein | [23] |
| Smatg12 | SMAC_06998 | Ubiquitin-like protein | [34] |
| Smjlb1 | SMAC_08510 | bZIP transcription factor | [24] |
| Smnbr1 | SMAC_07844 | Autophagy cargo receptor | [40] |
| Secondary metabolism | |||
| fbm1 | SMAC_00522 | Monooxygenase | [16] |
| pks4 | SMAC_05695 | Reducing polyketide synthase | [27] |
| pks | SMAC_03130 | Polyketide synthase (melanin biosynthesis) | [10] |
| sdh | SMAC_02101 | Scytalone dehydratase (melanin biosynthesis) | [10] |
| tih | SMAC_05650 | Trihydroxynaphtalene reductase (melanin biosynthesis) | [10, 22] |
| Transcription factors and mating-type genes | |||
| asm2 | SMAC_09436 | GAL4-like zinc cluster transcription factor | [38] |
| mcm1 | SMAC_05219 | MADS-box transcription factor | [8] |
| pro1 | SMAC_00338 | C6 zinc finger transcription factor | [1] |
| pro44 | SMAC_03223 | GATA-type transcription factor | [22, 38] |
| Smta-1 | SMAC_05404 | MAT1–2-1, HMG domain transcription factor | [9] |
| SmtA-2 | SMAC_05402 | MAT1–1-2, PPF domain protein | [18] |
| ste12 | SMAC_06479 | Homeodomain/zinc finger transcription factor | [7] |
| Chromatin modifiers | |||
| asf1 | SMAC_08608 | H3/H4 histone chaperone | [21, 38] |
| cac2 | SMAC_01629 | Putative subunit of CAF-1 (chromatin assembly factor 1) | [21, 38, 39] |
| crc1 | SMAC_02795 | CRC domain protein | [38, 39] |
| rtt106 | SMAC_03589 | Putative H3/H4 histone chaperone | [21, 38, 39] |
| scm1 | SMAC_04946 | SAS4 domain protein | [39] |
| spt3 | SMAC_01829 | Putative subunit of the SAGA complex | [39] |
| Pheromones and pheromone receptors | |||
| ppg1 | SMAC_05970 | Peptide pheromone | [5] |
| ppg2 | SMAC_12967 | Lipopeptide pheromone | [6] |
| pre1 | SMAC_02283 | Pheromone receptor | [6] |
| pre2 | SMAC_08994 | Pheromone receptor | [6] |
| Signal transduction | |||
| gsa1 | SMAC_05328 | G protein α-subunit | [13] |
| gsa2 | SMAC_06605 | G protein α-subunit | [13] |
| gsa3 | SMAC_07195 | G protein α-subunit | [13] |
| sac1 | SMAC_01638 | Adenylate cyclase | [13] |
| Subunits of the STRIPAK complex | |||
| pp2Ac1 | SMAC_04678 | Catalytic subunit of protein phosphatase 2A | [33] |
| pro11 | SMAC_08794 | Striatin | [3] |
| pro22 | SMAC_02580 | STRIP | [17, 20] |
| pro45 | SMAC_01224 | SLMAP | [31] |
| SCI1 | SMAC_05559 | STRIPAK complex interactor 1 | [37] |
| Smgpi1 | SMAC_12074 | GPI-anchored protein | [29] |
| Smkin3 | SMAC_04490 | Germinal center kinase | [30, 36] |
| Smkin24 | SMAC_01456 | Germinal center kinase | [30] |
| Smmob3 | SMAC_00877 | Phocein | [19] |
| MAPK signaling | |||
| mak1 | SMAC_05504 | MAPK of CWI pathway | [28] |
| mek1 | SMAC_02183 | MAPK kinase (MAPKK) of CWI pathway | [28] |
| mik1 | SMAC_03673 | MAPK kinase kinase (MAPKKK) of CWI pathway | [28] |
| pro40 | SMAC_04815 | Scaffold protein for CWI pathway | [11, 28] |
| NOX complex | |||
| nor1 | SMAC_02124 | NOX regulator | [25] |
| nox1 | SMAC_05007 | NADPH oxidase | [25] |
| nox2 | SMAC_08741 | NADPH oxidase | [25] |
| pro41 | SMAC_04848 | ER membrane protein, NoxD homolog | [12] |
| Genes without known domains or known molecular functions | |||
| spd4 | SMAC_01964 | – | [35] |
CWI, cell wall integrity pathway; ER, endoplasmic reticulum; GPI, glycosylphosphatidylinositol; MAPK, mitogen-activated protein kinase; NOX, NADPH oxidase; SAGA, Spt-Ada-Gcn5 histone acetyltransferase; SLMAP, sarcolemmal membrane-associated protein; SNARE, soluble N-ethylmaleimide-sensitive-factor attachment protein receptor; STRIPAK, striatin-interacting phosphatase and kinase; STRIP, striatin-interacting protein