Table 2.

Association among alcohol consumption, ALDH2 rs671 polymorphism, ADH1B rs1229984 polymorphism, and breast cancer risk.

	Cases		Controls		Odds ratio a	P	Odds ratio b	P	Odds ratio c	P
	N	%	N	%
Alcohol consumption
Never	391	62.8	1252	67.9	1 (ref)		1 (ref)		1 (ref)
Ever	232	37.2	593	32.1	1.25 (1.03–1.51)	0.020	1.27 (1.01–1.61)	0.042	1.38 (1.08–1.76)	0.010
≤12 g ethanol/day	150	24.1	467	25.3	1.03 (0.83–1.27)	0.799	1.11 (0.85–1.44)	0.441	1.20 (0.91–1.57)	0.189
>12 g ethanol/day	43	6.9	56	3.0	2.46 (1.62–3.71)	<0.001	2.15 (1.28–3.59)	0.004	2.38 (1.41–4.01)	0.001
ALDH2 rs671 genotype
Codominant model
GG	1318	71.4	428	68.7	1 (ref)		1 (ref)		1 (ref)
GA	483	26.2	175	28.1	1.12 (0.91–1.37)	0.294	1.14 (0.89–1.45)	0.306	1.26 (0.98–1.63)	0.074
AA	44	2.4	20	3.2	1.40 (0.80–2.37)	0.222	1.44 (0.71–2.84)	0.297	1.67 (0.82–3.31)	0.151
Dominant model
GG	1318	71.4	428	68.7	1 (ref)		1 (ref)		1 (ref)
GA/AA	527	28.6	195	31.3	1.14 (0.96–1.35)	0.194	1.16 (0.91–1.47)	0.222	1.29 (1.00–1.65)	0.045
Additive model
Increment of A	—	—	—	—	1.14 (0.93–1.39)	0.139	1.16 (0.94–1.42)	0.173	1.27 (1.02–1.58)	0.032
ADH1B rs1229984 genotype
Co-dominant model
TT	1036	56.2	358	57.8	1 (ref)		1 (ref)		1 (ref)
TC	687	37.2	231	37.3	0.74 (0.80z–1.18)	0.780	0.91 (0.72–1.15)	0.446	0.91 (0.72–1.15)	0.435
CC	122	6.6	30	4.8	0.71 (0.46–1.07)	0.110	0.70 (0.42–1.14)	0.164	0.71 (0.42–1.16)	0.178
Dominant model
TT	1036	56.2	358	57.8	1 (ref)		1 (ref)		1 (ref)
TC/CC	809	43.8	261	47.2	0.93 (0.78–1.12)	0.495	0.88 (0.71–1.10)	0.275	0.88 (0.71–1.10)	0.274
Additive model
Increment of C	—	—	—	—	0.91 (0.78–1.06)	0.224	0.88 (0.73–1.05)	0.165	0.88 (0.73–1.06)	0.171

^aUnadjusted odds ratio; ^bAdjusted for age at menarche, age at first full term pregnancy, age at menopause, body mass index, and smoking status; ^cAdditionally adjusted for alcohol consumption (for the association with ALDH2 or ADH1B) or ALDH2/ADH1B (for the association with alcohol consumption).