Table 3.
Association between alcohol consumption and breast cancer risk according to ALDH2 rs671 or ADH1B rs1229984 polymorphism.
| Cases | Controls | Odds ratioa | P-value | Odds ratiob | P-value | |||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | |||||
| ALDH2 rs671 genotype; GG | ||||||||
| Alcohol consumption | ||||||||
| Never | 225 | 52.6 | 801 | 60.8 | 1 (ref) | 1 (ref) | ||
| Ever | 203 | 47.4 | 517 | 39.2 | 1.40 (1.12–1.74) | 0.003 | 1.54 (1.17–2.04) | 0.002 |
| ≤12 g ethanol/day | 129 | 30.1 | 404 | 30.7 | 1.14 (0.89–1.45) | 0.301 | 1.33 (0.98–1.81) | 0.064 |
| >12 g ethanol/day | 41 | 9.6 | 52 | 3.9 | 2.81 (1.81–4.33) | <0.001 | 2.57 (1.45–4.53) | 0.001 |
| ALDH2 rs671 genotype; GA/AA | ||||||||
| Alcohol consumption | ||||||||
| Never | 166 | 85.1 | 451 | 85.6 | 1 (ref) | 1 (ref) | ||
| Ever | 29 | 14.9 | 76 | 14.4 | 1.04 (0.64–1.63) | 0.879 | 1.34 (0.73–2.41) | 0.336 |
| ≤12 g ethanol/day | 21 | 10.8 | 63 | 12.0 | 0.91 (0.52–1.51) | 0.711 | 1.15 (0.58–2.20) | 0.685 |
| >12 g ethanol/day | 2 | 1.0 | 4 | 0.8 | 1.36 (0.19–7.03) | 0.725 | 3.73 (0.45–24.11) | 0.171 |
| ADH1B rs1229984 genotype; TT | ||||||||
| Alcohol consumption | ||||||||
| Never | 224 | 62.6 | 704 | 68.0 | 1 (ref) | 1 (ref) | ||
| Ever | 134 | 37.4 | 332 | 32.0 | 1.27 (0.99–1.63) | 0.063 | 1.58 (1.15–2.17) | 0.005 |
| ≤12 g ethanol/day | 85 | 23.7 | 264 | 25.5 | 1.01 (0.76–1.34) | 0.936 | 1.32 (0.93–1.88) | 0.121 |
| >12 g ethanol/day | 28 | 7.8 | 32 | 3.1 | 2.75 (1.61–4.67) | <0.001 | 2.97 (1.49–5.94) | 0.002 |
| ADH1B rs1229984 genotype; TC/CC | ||||||||
| Alcohol consumption | ||||||||
| Never | 163 | 62.5 | 548 | 67.7 | 1 (ref) | 1 (ref) | ||
| Ever | 98 | 37.5 | 261 | 32.3 | 0.26 (0.94–1.69) | 0.116 | 1.24 (0.86–1.79) | 0.250 |
| ≤12 g ethanol/day | 65 | 24.9 | 203 | 25.1 | 1.08 (0.77–1.49) | 0.661 | 1.10 (0.73–1.66) | 0.634 |
| >12 g ethanol/day | 15 | 5.7 | 24 | 3.0 | 2.10 (1.06–4.06) | 0.030 | 1.93 (0.81–4.48) | 0.128 |
| ALDH2 rs671 & ADH1B rs1229984 genotype; GG and TT | ||||||||
| Alcohol consumption | ||||||||
| Never | 133 | 52.6 | 449 | 60.8 | 1 (ref) | 1 (ref) | ||
| Ever | 120 | 47.4 | 289 | 39.2 | 1.40 (1.05–1.87) | 0.021 | 1.76 (1.22–2.57) | 0.003 |
| ≤12 g ethanol/day | 75 | 29.6 | 226 | 30.6 | 1.12 (0.81–1.55) | 0.493 | 1.46 (0.97–2.21) | 0.068 |
| >12 g ethanol/day | 27 | 10.7 | 30 | 4.1 | 3.04 (1.74–5.30) | <0.001 | 3.37 (1.59–7.22) | 0.002 |
| ALDH2 rs671 and ADH1B rs1229984 genotype; GA or TC | ||||||||
| Alcohol consumption | ||||||||
| Never | 216 | 67.9 | 682 | 72.3 | 1 (ref) | 1 (ref) | ||
| Ever | 102 | 32.1 | 261 | 27.7 | 1.23 (0.93–1.62) | 0.135 | 1.21 (0.85–1.70) | 0.291 |
| ≤12 g ethanol/day | 70 | 22 | 205 | 21.7 | 1.08 (0.79–1.47) | 0.636 | 1.09 (0.74–1.60) | 0.660 |
| >12 g ethanol/day | 14 | 4.4 | 23 | 2.4 | 1.92 (0.95–3.76) | 0.060 | 1.76 (0.73–4.08) | 0.197 |
| ALDH2 rs671 and ADH1B rs1229984 genotype; AA or CC | ||||||||
| Alcohol consumption | ||||||||
| Never | 39 | 79.6 | 121 | 73.8 | 1 (ref) | 1 (ref) | ||
| Ever | 10 | 20.4 | 43 | 26.2 | 0.72 (0.32–1.52) | 0.410 | 0.95 (0.32–2.68) | 0.928 |
| ≤12 g ethanol/day | 5 | 10.2 | 36 | 22 | 0.43 (0.14–1.09) | 0.100 | 0.63 (0.14–2.25) | 0.506 |
| >12 g ethanol/day | 2 | 4.1 | 3 | 1.8 | 2.07 (0.27–12.92) | 0.435 | 1.70 (0.12–25.00) | 0.681 |
aUnadjusted odds ratio; bAdjusted for age, age at menarche, age at first full term pregnancy, age at menopause, body mass index, and smoking status.