Table 4.
Association among alcohol consumption, ALDH2 rs671 polymorphism, ADH1B rs1229984 polymorphism, and breast cancer risk based on menopausal status.
| Premenopausal | Postmenopausal | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | Odds ratioa | P | N | % | N | % | Odds ratioa | P | |
| Alcohol consumption | ||||||||||||
| Never | 197 | 56.6 | 695 | 64.1 | 1 (ref) | 187 | 73.3 | 557 | 73.3 | 1 (ref) | ||
| Ever | 151 | 43.4 | 390 | 35.9 | 1.75 (1.27–2.43) | 0.001 | 68 | 26.7 | 203 | 26.7 | 1.30 (0.85–1.96) | 0.222 |
| ≤12 g ethanol/day | 99 | 28.4 | 309 | 28.5 | 1.53 (1.08–2.18) | 0.018 | 43 | 16.9 | 158 | 20.8 | 1.09 (0.69–1.73) | 0.717 |
| >12 g ethanol/day | 33 | 9.5 | 41 | 3.8 | 2.87 (1.52–5.40) | 0.001 | 9 | 3.5 | 15 | 2.0 | 2.40 (0.72–7.63) | 0.144 |
| ALDH2 rs671 genotype | ||||||||||||
| Co-dominant model | ||||||||||||
| GG | 246 | 70.7 | 759 | 70 | 1 (ref) | 168 | 65.9 | 559 | 73.6 | 1 (ref) | ||
| GA | 90 | 25.9 | 301 | 27.7 | 1.03 (0.73–1.46) | 0.860 | 80 | 31.4 | 182 | 23.9 | 1.67 (1.12–2.49) | 0.011 |
| AA | 12 | 3.4 | 25 | 2.3 | 2.12 (0.84–5.15) | 0.102 | 7 | 2.7 | 19 | 2.5 | 1.12 (0.32–3.49) | 0.846 |
| Dominant model | ||||||||||||
| GG | 246 | 70.7 | 759 | 70 | 1 (ref) | 168 | 65.9 | 559 | 73.6 | 1 (ref) | ||
| GA/AA | 102 | 29.3 | 326 | 30 | 1.10 (0.78–1.54) | 0.594 | 87 | 34.1 | 201 | 26.4 | 1.63 (1.10–2.40) | 0.014 |
| Additive model | ||||||||||||
| Increment of A | — | — | — | — | 1.16 (0.86–1.56) | 0.326 | — | — | — | — | 1.45 (1.03–2.05) | 0.032 |
| ADH1B rs1229984 genotype | ||||||||||||
| Co-dominant model | ||||||||||||
| TT | 204 | 59.1 | 628 | 57.9 | 1 (ref) | 142 | 55.9 | 408 | 53.7 | 1 (ref) | ||
| TC | 123 | 35.7 | 385 | 35.5 | 1.03 (0.75–1.41) | 0.872 | 100 | 39.4 | 302 | 39.7 | 0.80 (0.56–1.15) | 0.227 |
| CC | 18 | 5.2 | 72 | 6.6 | 0.85 (0.43–1.62) | 0.637 | 12 | 4.7 | 50 | 6.6 | 0.56 (0.23–1.27) | 0.182 |
| Dominant model | ||||||||||||
| TT | 204 | 59.1 | 628 | 57.9 | 1 (ref) | 142 | 55.9 | 408 | 53.7 | 1 (ref) | ||
| TC/CC | 141 | 40.9 | 457 | 42.1 | 1.00 (0.74–1.35) | 0.999 | 112 | 44.1 | 352 | 46.3 | 0.77 (0.54–1.09) | 0.142 |
| Additive model | ||||||||||||
| Increment of C | — | — | — | — | 0.98 (0.76–1.25) | 0.842 | — | — | - | — | 0.78 (0.58–1.04) | 0.098 |
| ALDH2 rs671 and ADH1B rs1229984 genotype | ||||||||||||
| GG and TT | 148 | 42.9 | 438 | 40.4 | 1 (ref) | 98 | 38.6 | 300 | 39.5 | 1 (ref) | ||
| GA or TC | 168 | 48.7 | 551 | 50.8 | 1.02 (0.74–1.40) | 0.915 | 138 | 54.3 | 392 | 51.6 | 1.10 (0.77–1.59) | 0.607 |
| AA or CC | 29 | 8.4 | 96 | 8.8 | 1.09 (0.61–1.90) | 0.772 | 18 | 7.1 | 68 | 8.9 | 0.68 (0.32–1.40) | 0.313 |
aAdjusted for age, age at menarche, age at first full term pregnancy, age at menopause, body mass index, smoking status, and alcohol consumption (for the association with ALDH2 or ADH1B) or ALDH2/ADH1B (for the association with alcohol consumption).