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. 2020 Apr 16;10:6560. doi: 10.1038/s41598-020-63482-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CDDO-Me increases the proportion of CD8⁺ T cells and reduces Treg numbers in tumors in vivo. Whole mammary/tumor tissue of mice fed diet with or without 50 mg/kg CDDO-Me for 8 weeks was digested to a single cell suspension and analyzed by multicolor flow cytometry for analysis of CD4 + and CD8+ T cell populations (a). Dual positive CD4/Foxp3 T cell percentages were compared in control and CDDO-Me-treated mice (b). Expression of PD1 on CD8+ T cells was assessed using mean fluorescence intensity (MFI) (b). Where indicated, expression of surface markers is represented as percentage of cells positive for the respective marker (n = 5–10 per group). *p < 0.05, **p < 0.01, ***p < 0.005 vs. vehicle.