Table 3.
Pharmacokinetic properties of compounds 9-23, 30 and 31.
| Comp. | Ar | Exp. Log P | TPSA(Å) | MW | nON | nOHNH | nviolat. | nrot | %ABS |
|---|---|---|---|---|---|---|---|---|---|
| 9 | ![]() |
1.59 | 48.02 | 393 | 5 | 0 | 0 | 3 | 92.43 |
| 10 | ![]() |
1.44 | 57.26 | 423 | 6 | 0 | 0 | 4 | 89.24 |
| 11 | ![]() |
0.23 | 65.10 | 421 | 6 | 0 | 0 | 4 | 86.54 |
| 12 | ![]() |
1.48 | 48.02 | 443 | 5 | 0 | 0 | 3 | 92.43 |
| 13 | ![]() |
1.26 | 48.02 | 411 | 5 | 0 | 0 | 3 | 92.43 |
| 14 | ![]() |
1.63 | 48.02 | 399 | 5 | 0 | 0 | 3 | 92.43 |
| 15 | ![]() |
1.54 | 48.02 | 407 | 5 | 0 | 0 | 3 | 92.43 |
| 16 | ![]() |
1.74 | 48.02 | 421 | 5 | 0 | 0 | 4 | 92.43 |
| 17 | ![]() |
1.41 | 65.10 | 435 | 6 | 0 | 0 | 4 | 86.54 |
| 18 | ![]() |
1.34 | 48.02 | 427 | 5 | 0 | 0 | 3 | 92.43 |
| 19 | ![]() |
2.05 | 48.02 | 472 | 5 | 0 | 0 | 3 | 92.43 |
| 20 | ![]() |
1.88 | 57.26 | 423 | 6 | 0 | 0 | 4 | 89.24 |
| 21 | ![]() |
1.77 | 48.02 | 411 | 5 | 0 | 0 | 3 | 92.43 |
| 22 | ![]() |
1.37 | 48.02 | 399 | 5 | 0 | 0 | 3 | 92.43 |
| 23 | ![]() |
1.67 | 48.02 | 461 | 5 | 0 | 0 | 4 | 92.43 |
| 30 | ![]() |
2.16 | 65.85 | 515 | 7 | 0 | 1 | 4 | 86.28 |
| 31 | ![]() |
1.77 | 65.85 | 515 | 7 | 0 | 1 | 4 | 86.28 |
TPSA = Total polar surface area, nON = no. of hydrogen acceptors, nOHON = no. of hydrogen donors, nrot = number of rotational bonds, % ABS = percentage of absorbance.
















